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A limited survey-based uncontrolled follow-up study of children born after ooplasmic transplantation in a single centre

Reproductive BioMedicine Online,Volume 33, Issue 6, December 2016, Pages 737–744

Abstract

Experimental ooplasmic transplantation from donor to recipient oocyte took place between 1996 and 2001 at Saint Barnabas Medical Center, USA. Indication for 33 patients was repeated implantation failure. Thirteen couples had 17 babies. One patient delivered twins from mixed ooplasmic and donor egg embryos. A limited survey-based follow-up study on the children is reported: 12 out of 13 parents completed a questionnaire on pregnancy, birth, health, academic performance and disclosure. Parents of a quadruplet did not participate. Prenatal development and delivery were uneventful. School grades ranged from good to excellent. Children were of good health. Body mass index (BMI) was normal in 12 out of 13 children. One child had chronic migraine headaches, two mild asthma, three minor vision and three minor skin problems. One boy from a boy/girl twin was diagnosed with borderline pervasive developmental disorder – not otherwise specified at age 18 months, but with no later symptoms. One couple disclosed the use of egg donor to their child. One reported intention to disclose; six were undecided and four reported they would not disclose. This limited follow-up strategy presents a high risk of bias. Parents may not assent to standardized clinical analysis owing to lack of disclosure to their children.

Keywords: cytoplasmic transfer, repeated implantation failure, survey, limited follow-up, disclosure to children.

Footnotes

a Institute for Reproductive Medicine and Science at Saint Barnabas Medical Center, Livingston, NJ 07039, USA

b ART Institute of Washington, Livingston, NJ 07039, USA

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