Welcome to the UIT Fertility Resource Centre hosted by Reproductive Biomedicine Online and published by Elsevier. Funded by Ferring, this resource centre provides access to the latest literature on infertility treatment. The site features peer-reviewed articles, video material from UIT and other academic symposia, interviews with eminent researchers, Netter images and medical surveys. Please sign up to the E-Alert when you would like to keep up with the new content updates.
Long-term breast cancer risk following ovarian stimulation in young egg donors: a call for follow-up, research and informed consent
Jennifer Schneider, Jennifer Lahl, Wendy Kramer
Reproductive BioMedicine Online, Volume 34, Issue 5, May 2017, Pages 480 - 485
Oocyte donation is a complicated procedure with biological, ethical and moral implications that lasts for a lifetime or even longer. Proper monitoring of the long-term effects of the procedure on oocyte donors undoubtedly requires formation of registries, an effort dwarfed by the concerns about privacy. Schneider and co-authors discuss these complicated issues based on five cases of breast cancer.
In vitro culture of individual mouse preimplantation embryos: the role of embryo density, microwells, oxygen, timing and conditioned media
Rebecca L. Kelley, David K. Gardner
Reproductive BioMedicine Online, Volume 34, Issue 5, May 2017, Pages 441 - 454
Many basic aspects of embryo culture are somewhat controversial. The increasing use of time-lapse monitoring systems led to more embryos being cultured individually in micro wells. In an elegantly designed set of experiments, Kelley and Gardner, explore the effects of group vs individual embryo culture, culture media volume, and whether possible adverse effects of individual culture can be negated using embryo-conditioned media. I believe this paper also provides a good overview of the subject for the clinicians, thus it is a must read both for embryologists and ART physician.
The effect of elevated progesterone levels before HCG triggering in modified natural cycle frozen-thawed embryo transfer cycles
Eva R. Groenewoud, Nick S. Macklon, Ben J. Cohlen, on behalf of the, ANTARCTICA Study Group1 (Amani Al-Oraiby, Egbert A. Brinkhuis, Frank J.M. Broekmans, Jan-Peter de Bruin, Grada van der Dool, Kathrin Fleisher, Jaap Friederich, Mariëtte Goddijn, Annemieke Hoek, Diederik A. Hoozemans, Eugenie M. Kaaijk, Carolina A.M. Koks, Joop S.E. Laven, Paul J.Q. van der Linden, A. Petra Manger, Minouche van Rumpste, Taeke Spinder).
Reproductive BioMedicine Online, Volume 34, Issue 5, May 2017, Pages 546 - 554
Increased progesterone levels during the late follicular phase adversely affect pregnancy rates after fresh embryo transfer. Logically, one would expect to observe a similar effect in frozen embryo transfer cycles. Yet, the incidence of premature progesterone rise and its effect on clinical outcome can vary between different endometrial preparation protocols. In this secondary analysis of randomized controlled trial data, Groenewoud and colleagues present interesting findings which can make you reconsider your practice.
Views of Prof Dr Bart Fauser On “Is infertility treatment a good example of the personalisation of medicine”
How to Design a Study -Nikolaos P. Polyzos gives a comparison of various study designs, and considerations such as randomization procedures and ethical considerations.
How to Write an Abstract - Paul Devroey suggests preferred types of abstract and study, explains how it is of paramount importance to initiate a correct study design, with retrospective and historical nature to be avoided.
How to Write a Scientific Article - Nikolaos P. Polyzos offers advice on how to create a meaningful title, and how to structure the article into a coherent abstract, material and methods, results, discussion.
How to Critically Appraise a Study - Nikolaos P. Polyzos states that you should not accept the conclusions of any paper without question, and provides guidance of how to question these conclusions.
View and download all available Netter images at our Image bank.